THANOS ON DEFENSE
Of course there’s Protected – for 8 points you can ignore one attack. I think this is an absolute must. Thanos may have an [18] Defense win Invulnerability, but one good Penetrating/Psychic Blast or a little outwit and he’s going to tumble. You can try Fortitude too, but it’s not worth it in my opinion since he has so few powers that need immunity.

Continued below...

I am a fan of Shellhead though – you’re going to need to push Thanos a lot to get your 185 points worth. And that extra 2 defense is pretty high for just 10 points, especially if you have to deal with a lot of Incapacitate.

Sadly, the end Regeneration won't do much -- the chance of you landing on that click is pretty low.. and even if you do, you may have to push to regen, which could still lead to death on a bad roll