#5 ISSUE 378
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Chosen by the Northeast Ohio HeroCix group's Neal Nelan, this 1993 classic featured four villains: Carnage (Cletus Kasady), Shriek, Spider-Man Doppelganger, and Demogoblin! The good news is that the issue didn't suck like the Spider-Man 3 movie did!

From Marvel Wikia:
"Part 3 of "Maximum Carnage" - Eddie Brock arrives at Laguardia Airport. He sees a newspaper concerning a headline involving Carnage. He speaks aloud concerning his intention to kill Carnage, and transforms into Venom. When Airport security clumsily attempts to apprehend him, he flees. While he approaches the city, Venom laments how he feels responsible for Carnage, as his symbiote created him.

Meanwhile, Cloak and Spider-Man are nursing their wounds in the Holy Ghost Church. Cloak is beside himself with grief from losing Dagger to a surprise assault by Shriek. He expresses grief and then rage, swearing to make Shriek pay. Spider-Man then leaves to pursue leads concerning Carnage. Spider-Man, while searching, considers the fact that Carnage has teamed up with the Doppleganger and Shriek and how death and life work in a balance."